Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making.

Risk of Contralateral Breast Cancer Associations With Histologic, Clinical, and Therapeutic Factors PAMELA L. HORN, PHD, AND W. DOUGLAS THOMPSON, PHD A case-control study was conducted to assess the risk factors associated with the development of a

Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women Journal of the National Cancer Institute 2020-03-02 And the benefits of tamoxifen lasted: Even 5 years after a woman stopped taking tamoxifen, her risk of contralateral breast cancer was lower than a woman who had never taken hormonal therapy. Women who took only an aromatase inhibitor had about a 52% lower risk of developing breast cancer in the opposite breast compared to women who didn’t take hormonal therapy. Prophylactic contralateral (CLT) breast radiotherapy was associated with significantly fewer and delayed cases of breast cancer in women having standard therapy for their ipsilateral BRCA mutation-associated breast cancers in a study from Israel reported in a poster session at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting . The risk of contralateral breast cancer was elevated among cohort members who reported a history of breast cancer in a first-degree relative (multivariable-adjusted rate ratio (RR) = 1.91, 95% Tamoxifen protected against contralateral breast cancer for carriers of BRCA1 mutations (odds ratio 0·38, 95% Cl 0·19–0·74) and for those with BRCA2 mutations (0·63, 0·20–1·50). In women who used tamoxifen for 2–4 years, the risk of contralateral breast cancer was reduced by 75%. ARTICLE Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk Iris Kramer, 1Maartje J. Hooning,2 Nasim Mavaddat,3 Michael Hauptmann,4,5 Renske Keeman, Ewout W. Steyerberg, 6 ,7 Daniele Giardiello,1 Antonis C. Antoniou, 3Paul D.P. Pharoah, 8 Sander Canisius,1,9 Zumuruda Abu-Ful,10 Irene L. Andrulis,11,12 Hoda Anton-Culver,13 Kristan J. Aronson,14 Annelie Augustinsson,15 Heiko On CRR, 5- and 10-year rates were 2.9 and 5.8% for CBC, and 7.8 and 14.5% for IBTR.

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Assessment of risk of contralateral breast cancer in high-risk patients and formulation of clinical guidelines The Degree of Doctor of Medicine – University of Manchester Narendra Nath Basu – June 2016 Breast cancer is the most common female cancer worldwide. Patterns of Further analysis of the patients with contralateral breast cancer revealed that a five-year Gail risk of 1.67 percent or greater; an invasive lobular histology; and multiple tumors in the original An increasing number of breast cancer patients are undergoing expanded genetic testing and are being identified as germline mutation carriers. We sought to determine rates of contralateral risk-reducing mastectomy (CRRM) in patients with various germline mutations. All women ≥ 18 years of age with unilateral breast cancer who underwent multigene panel testing between January 1, 2014 and Whether these drugs can be used to prevent breast cancer in women at much higher risk, such as women with harmful mutations in BRCA1 or BRCA2 or other breast cancer susceptibility genes, is not yet clear, although tamoxifen may be able to help lower the risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers previously diagnosed with breast cancer . For each of the 3 analyses (breast cancer risk, contralateral breast cancer risk, and ovarian cancer risk), we defined a different group eligible at baseline . Age at baseline was defined as age at study recruitment or age at the genetic test, whichever was more recent.

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Background. Women who receive tamoxifen or chemotherapy as treatment for breast cancer are at reduced risk of developing contralateral breast cancer (CBC) according to findings from randomized trials [1, 2] and observational studies [3–9].Nonetheless, several unresolved questions regarding these associations remain.

The ratio between ipsi- and contralateral used increased steadily with increasing. development of arm lymphedema following breast cancer treatment: A match Weingrad DN, Davey S. Local tissue water in at-risk and contralateral forearms.

density as a risk factor for contralateral breast cancer , studying both mammographic density at diagnosis of the first cancer and changes in density following the first cancer. We find no effect on the risk of contralateral breast cancer by mammographic density at the time of diagnosis of the first cancer ;

We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making.

It's the second deadliest cancer for women in the United States, with only lung cancer causing more deaths in females.
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AKADEMISK AVHANDLING som för avläggande av medicine doktorsexamen vid Karolinska. Contralateral (and ipsilateral) riskreducing mastectomy *Previous diagnosis of breast cancer in the contralateral breast; age refers to age at diagnosis of the  99351 avhandlingar från svenska högskolor och universitet. Avhandling: Contralateral Breast Cancer : Risk and Prognosis.

All women ≥ 18 years of age with unilateral breast cancer who underwent multigene panel testing between January 1, 2014 and Bottom Line: Women with BRCA1 or BRCA2 mutations who underwent adjuvant tamoxifen for breast cancer have a reduced risk of contralateral (other side) breast cancer. The Study: Investigators used the International BRCA1 and BRCA2 Carrier Cohort Study, the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer, and the Breast Cancer Family Registry to identify women 2021-03-31 · A multicenter, individually-matched case-control study was performed to explore the relationship between radiation therapy (RT), smoking, and risk of contralateral breast cancer (CBC). Researchers enrolled 1,521 CBC cases and 2,212 controls with unilateral breast cancer; first invasive breast cancer was diagnosed in all between 1985–2008 at age < 55 years. Prophylactic contralateral (CLT) breast radiotherapy was associated with significantly fewer and delayed cases of breast cancer in women having standard therapy for their ipsilateral BRCA mutation-associated breast cancers in a study from Israel reported in a poster session at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting .
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8 Jan 2014 Nevertheless, this procedure is the most drastic measure someone could take in combating the risk of breast cancer. There are other alternatives 

av S Gottlieb · 2001 — The researchers identified contralateral breast cancers in 89 of the tamoxifen users and 100 of the non-users. Of these 189 women, 112 had  The association between FBCH and radiation-induced breast cancer risk was For whole breast standard radiotherapy at age 40 with a contralateral breast  Contralateral (and ipsilateral) riskreducing mastectomy *Previous diagnosis of breast cancer in the contralateral breast; age refers to age at diagnosis of the  99351 avhandlingar från svenska högskolor och universitet. Avhandling: Contralateral Breast Cancer : Risk and Prognosis.